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14th World Congress on Personalized Medicine and Novel Therapy, will be organized around the theme “Exploring Innovations and Knowledge of Personalized Medicine”

Personalised Medicine 2021 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Personalised Medicine 2021

Submit your abstract to any of the mentioned tracks.

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Genomic medicine attempts to build individualized strategies for diagnostic or therapeutic decision-making by utilizing patients’ genomic information. Big Data analytics uncovers hidden patterns, unknown correlations, and other insights through examining large-scale various datasets. While integration and manipulation of diverse genomic data and comprehensive electronic health records (EHRs) on a Big Data infrastructure exhibit challenges, they also provide a feasible opportunity to develop an efficient and effective approach to identify clinically actionable genetic variants for individualized diagnosis and therapy. In this paper, we review the challenges of manipulating large-scale next-generation sequencing (NGS) data and diverse clinical data derived from the EHRs for genomic medicine. We introduce possible solutions for different challenges in manipulating, managing, and analyzing genomic and clinical data to implement genomic medicine.

A few components need to meet up for an individual to create type 2 diabetes. Components like sustenance and exercise are critical. Be that as it may, type 2 diabetes additionally has a solid hereditary segment. Diabetes comprises a noteworthy general medical issue. Albeit generous advancement has been made in characterizing the hereditary hazard for explicit subtypes of diabetes .The weight of diabetes is a lot higher for racial/ethnic minorities than for whites. Minorities have a higher predominance of diabetes than whites, and a few minorities have higher paces of diabetes-related entanglements and passing. Research results help in understanding these aberrations and approaches to lessen them. Huge advances have been made lately in connection to the pathogenesis of T2DM. This has fundamentally improved our insight into one of the most genuine wellbeing dangers on the planet, permitting recognizable proof of qualities and pathways associated with the advancement and movement of the infection. It has as of late turned out to be conceivable to get atomic and hereditary level data.

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It is admirable to discuss about clinical neuroscience as this focuses on the fundamental mechanisms of diseases and disorders of the brain and central nervous system and seeks to develop new ways of diagnosing such anarchy, leading to the development of novel medication. As per the estimates by the World Health Organization, neural disorders affect over 1 billion people worldwide, constitute 12% of the burden of disease globally, and cause 14% of global annihilation. Basing on the prevalence of diseases, the conference focuses on Post-surgical neuralgias, Brain tumour and metastasis, Oncological neurosurgery, Spine surgery, Neuroanaesthesia and surgery and Vascular malfunctions and surgery. Highest incidence rate of primary intracranial tumour was in Europe and the lowest rate in Africa. So it is requisite to enhance our knowledge on current neurosurgery methods.

Gastrointestinal cancer refers to malignant conditions of the gastrointestinal (GI) tract and other organs involved in digestion, including the oesophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The symptoms relate to the organ affected and can include obstruction, abnormal bleeding and other associated problems.

 

Gastrointestinal cancer refers to malignant conditions of the gastrointestinal (GI) tract and other organs involved in digestion, including the oesophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The symptoms relate to the organ affected and can include obstruction, abnormal bleeding and other associated problems.

1. Lack of making different selections before initiating the discovery phase.

2. Robustness of analysis techniques used in clinical trials.

<p style="\&quot;box-sizing:" border-box;="" margin:="" 0px="" 10px;="" color:="" rgb(51,="" 51,="" 51);="" font-family:="" "helvetica="" neue",="" helvetica,="" arial,="" sans-serif;="" font-size:="" 14px;="" background-color:="" rgb(255,="" 255,="" 255);\"="">Each of these details is rarely documented and can dramatically affect the predictive outcome of biomarker results. However, the selection of useful biomarkers must be carefully assessed and depends on different important parameters, such as on sensitivity (it should correctly identify a high proportion of true positive rate), specificity (it should correctly identify a high proportion of true negative rate), predictive value etc. Unfortunately, biomarkers with ideal specificity and sensitivity are difficult to find. One potential solution is to use the combinatorial power of different biomarkers, each of which alone may not offer satisfaction in specificity or sensitivity.

<span style="\&quot;color:" rgb(51,="" 51,="" 51);="" font-family:="" "roboto="" slab",="" serif;="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);\"="">Precision medicine aims to provide the right treatment for the right patient at the right time with treatment directed on the basis of the targetable tumoral aberrations rather than just a traditional histologic subtype. However to facilitate this approach, clinicians require patient derived samples. Prostate cancer is challenging to culture in vitro. Recent development of novel organoid in vitro culture technology has led to the development of multiple new in vitro prostate cancer cell line models. We aim to apply organoid culture technology to develop novel in vitro prostate cancer cell line models and propagate patient derived samples to allow drug testing and next generation sequencing as part of a precision medicine approach to early recurrent prostate cancer.

\r\n Gene therapy is hoped to cure or improve treatment of genetic disorders by replacing the mutated or malfunctioned gene, manipulating or turning off the gene causing the disease or stimulate other bodily functions to fight the disease. The most common method is replacement of a malfunctioned or sometimes a missed gene with a healthy one. However, gene therapy poses a risk of potentially serious complications, in the first place due to the method that is used to insert the “new“ genes – the use of viruses. These have the ability to identify certain cells as well as to transmit the genetic material into the cells containing malfunctioned or missed gene. For that reason modified viruses are used as vectors or carriers of the healthy genes. This method of insertion of healthy genes may not seem problematic at a first glance but it can cause potentially serious complications as already mentioned earlier.

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