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14th World Congress on Personalized Medicine and Novel Therapy, will be organized around the theme “Exploring Innovations and Knowledge of Personalized Medicine”
Personalised Medicine 2021 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Personalised Medicine 2021
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Genomic medicine attempts to build individualized strategies for diagnostic or therapeutic decision-making by utilizing patients’ genomic information. Big Data analytics uncovers hidden patterns, unknown correlations, and other insights through examining large-scale various datasets. While integration and manipulation of diverse genomic data and comprehensive electronic health records (EHRs) on a Big Data infrastructure exhibit challenges, they also provide a feasible opportunity to develop an efficient and effective approach to identify clinically actionable genetic variants for individualized diagnosis and therapy. In this paper, we review the challenges of manipulating large-scale next-generation sequencing (NGS) data and diverse clinical data derived from the EHRs for genomic medicine. We introduce possible solutions for different challenges in manipulating, managing, and analyzing genomic and clinical data to implement genomic medicine.
A few components need to meet up for an individual to create type 2 diabetes. Components like sustenance and exercise are critical. Be that as it may, type 2 diabetes additionally has a solid hereditary segment. Diabetes comprises a noteworthy general medical issue. Albeit generous advancement has been made in characterizing the hereditary hazard for explicit subtypes of diabetes .The weight of diabetes is a lot higher for racial/ethnic minorities than for whites. Minorities have a higher predominance of diabetes than whites, and a few minorities have higher paces of diabetes-related entanglements and passing. Research results help in understanding these aberrations and approaches to lessen them. Huge advances have been made lately in connection to the pathogenesis of T2DM. This has fundamentally improved our insight into one of the most genuine wellbeing dangers on the planet, permitting recognizable proof of qualities and pathways associated with the advancement and movement of the infection. It has as of late turned out to be conceivable to get atomic and hereditary level data.
It is admirable to discuss about clinical neuroscience as this focuses on the fundamental mechanisms of diseases and disorders of the brain and central nervous system and seeks to develop new ways of diagnosing such anarchy, leading to the development of novel medication. As per the estimates by the World Health Organization, neural disorders affect over 1 billion people worldwide, constitute 12% of the burden of disease globally, and cause 14% of global annihilation. Basing on the prevalence of diseases, the conference focuses on Post-surgical neuralgias, Brain tumour and metastasis, Oncological neurosurgery, Spine surgery, Neuroanaesthesia and surgery and Vascular malfunctions and surgery. Highest incidence rate of primary intracranial tumour was in Europe and the lowest rate in Africa. So it is requisite to enhance our knowledge on current neurosurgery methods.
Gastrointestinal cancer refers to malignant conditions of the gastrointestinal (GI) tract and other organs involved in digestion, including the oesophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The symptoms relate to the organ affected and can include obstruction, abnormal bleeding and other associated problems.
The development of cost-effective technologies able to comprehensively assess DNA, RNA, protein, and metabolites in patient tumours has fuelled efforts to tailor medical care. Indeed validated molecular tests assessing tumour tissue or patient germ line DNA already drive therapeutic decision making. However, many theoretical and regulatory challenges must still be overcome before fully realizing the promise of personalized molecular medicine. The masses of data generated by high-throughput technologies are challenging to manage, visualize, and convert to the knowledge required to improve patient outcomes. Systems biology integrates engineering, physics, and mathematical approaches with biologic and medical insights in an iterative process to visualize the interconnected events within a cell that determine how inputs from the environment and the network rewiring that occurs due to the genomic aberrations acquired by patient tumours determines cellular behaviour and patient outcomes. A cross-disciplinary systems biology effort will be necessary to convert the information contained in multidimensional data sets into useful biomarkers that can classify patient tumours by prognosis and response to therapeutic modalities and to identify the drivers of tumour behaviour that are optimal targets for therapy. An understanding of the effects of targeted therapeutics on signalling networks and homeostatic regulatory loops will be necessary to prevent inadvertent effects as well as to develop rational combinatorial
Precision medicine aims to provide the right treatment for the right patient at the right time with treatment directed on the basis of the targetable tumoral aberrations rather than just a traditional histologic subtype. However to facilitate this approach, clinicians require patient derived samples. Prostate cancer is challenging to culture in vitro. Recent development of novel organoid in vitro culture technology has led to the development of multiple new in vitro prostate cancer cell line models. We aim to apply organoid culture technology to develop novel in vitro prostate cancer cell line models and propagate patient derived samples to allow drug testing and next generation sequencing as part of a precision medicine approach to early recurrent prostate cancer.
Gene therapy is hoped to cure or improve treatment of genetic disorders by replacing the mutated or malfunctioned gene, manipulating or turning off the gene causing the disease or stimulate other bodily functions to fight the disease. The most common method is replacement of a malfunctioned or sometimes a missed gene with a healthy one. However, gene therapy poses a risk of potentially serious complications, in the first place due to the method that is used to insert the “new“ genes – the use of viruses. These have the ability to identify certain cells as well as to transmit the genetic material into the cells containing malfunctioned or missed gene. For that reason modified viruses are used as vectors or carriers of the healthy genes. This method of insertion of healthy genes may not seem problematic at a first glance but it can cause potentially serious complications as already mentioned earlier.
Personalized medicine deals with providing the right drug, at the right dosage, to the right patient, at the right time. It provides a tailored management of a precise individual. This approach has been used in dermatology for decades. The available scientific literature has been reviewed in a trial to summarize the applications of personalized medicine in dermatological practice.
Palliative care that improves the quality of life and quality of care for patients with life threatening or life-limiting sickness and their families through the prevention and relief of suffering, communication about goals of care, and early identification and assessment and treatment of pain and other problems, physical, psychosocial and spiritual.
End-of-life care is care taking place in the last part of a patient’s life, typically in the last few months, depending on the primary diagnosis and clinical course and includes planning for end-of-life care.
Geriatrics is a specialty that focuses on health care of elderly people. It aims to promote health by preventing and treating diseases and disabilities in older adults. There is no set age at which patients may be under the care of a geriatrician or geriatric physician, a physician who specializes in the care of elderly people. Rather, this decision is determined by the individual patient's needs, and the availability of a specialist. Geriatrics differs from standard adult medicine because it focuses on the unique needs of the elderly person. The aged body is different physiologically from the younger adult body, and during old age, the decline of various organ systems becomes manifest. Previous health issues and lifestyle choices produce a different constellation of diseases and symptoms in different people.
Palliative care professionals say the problems that lead to supported dying requests can usually be dealt with in ways that do not accelerate death. They promote quality of life and reject the idea of “dying on demand”. Supporters of aided dying, argue that palliative care cannot be effective in every case. To them, the important thing is to respect independence and self-determination of choice.